エクスポート完了 — 
ロード中...

Type II RAF inhibitor causes superior ERK pathway suppression compared to type I RAF inhibitor in cells expressing different BRAF mutant types recurrently found in lung cancer

A large fraction of somatic driver BRAF mutations in lung cancer are non-V600 and impaired-kinase. Non-V600 BRAF mutations predict sensitivity to combination of a type I RAF inhibitor, Dabrafenib, and a MEK inhibitor, Trametinib. Singly, Dabrafenib only weakly suppresses mutant BRAF-induced ERK sign...

詳細記述

保存先:
書誌詳細
出版年:Oncotarget
主要な著者: Noeparast, Amir, Giron, Philippe, De Brakeleer, Sylvia, Eggermont, Carolien, De Ridder, Ulrike, Teugels, Erik, De Grève, Jacques
フォーマット: Artigo
言語:Inglês
出版事項: Impact Journals LLC 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882321/
https://ncbi.nlm.nih.gov/pubmed/29662630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24576
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!