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Glycosylation of MUC1 influences the binding of a therapeutic antibody by altering the conformational equilibrium of the antigen
In cancer cells, the glycoprotein Mucin 1 (MUC1) undergoes abnormal, truncated glycosylation. The truncated glycosylation exposes cryptic peptide epitopes that can be recognized by antibodies. Since these immunogenic regions are cancer specific, they represent ideal targets for therapeutic antibodie...
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| Udgivet i: | Glycobiology |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5881634/ https://ncbi.nlm.nih.gov/pubmed/28025250 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cww131 |
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