Inhibition of DNA methyltransferase leads to increased genomic 5‐hydroxymethylcytosine levels in hematopoietic cells

5‐Hydroxymethylcytosine (5hmC) is produced from 5‐methylcytosine (5mC) by Ten‐eleven translocation (TET) dioxygenases. The epigenetic modification 5hmC has crucial roles in both cellular development and differentiation. The 5hmC level is particularly high in the brain. While 5mC is generally associa...

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Publicat a:FEBS Open Bio
Autors principals: Vető, Borbála, Szabó, Pál, Bacquet, Caroline, Apró, Anna, Hathy, Edit, Kiss, Judit, Réthelyi, János M., Szeri, Flóra, Szüts, Dávid, Arányi, Tamás
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881552/
https://ncbi.nlm.nih.gov/pubmed/29632811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12392
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