The transcriptional activity of hepatocyte nuclear factor 4 alpha is inhibited via phosphorylation by ERK1/2

Hepatocyte nuclear factor 4 alpha (HNF4α) nuclear receptor is a master regulator of hepatocyte development, nutrient transport and metabolism. HNF4α is regulated both at the transcriptional and post-transcriptional levels by different mechanisms. Several kinases (PKA, PKC, AMPK) were shown to phosph...

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Publicat a:PLoS One
Autors principals: Vető, Borbála, Bojcsuk, Dóra, Bacquet, Caroline, Kiss, Judit, Sipeki, Szabolcs, Martin, Ludovic, Buday, László, Bálint, Bálint L., Arányi, Tamás
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5308853/
https://ncbi.nlm.nih.gov/pubmed/28196117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0172020
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