The ERK1/2-Hepatocyte Nuclear Factor 4α Axis Regulates Human ABCC6 Gene Expression in Hepatocytes

ABCC6 mutations are responsible for the development of pseudoxanthoma elasticum, a rare recessive disease characterized by calcification of elastic fibers. Although ABCC6 is mainly expressed in the liver the disease has dermatologic, ocular, and cardiovascular symptoms. We investigated the transcrip...

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Detalhes bibliográficos
Main Authors: de Boussac, Hugues, Ratajewski, Marcin, Sachrajda, Iwona, Köblös, Gabriella, Tordai, Attila, Pulaski, Lukasz, Buday, László, Váradi, András, Arányi, Tamás
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2906271/
https://ncbi.nlm.nih.gov/pubmed/20463007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105593
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