4-1BB costimulation induces T cell mitochondrial function and biogenesis enabling cancer immunotherapeutic responses

Despite remarkable responses to cancer immunotherapy in a subset of patients, many patients remain resistant to these therapies. The tumor microenvironment can impose metabolic restrictions on T cell function, creating a resistance mechanism to immunotherapy. We have previously shown tumor-infiltrat...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Menk, Ashley V., Scharping, Nicole E., Rivadeneira, Dayana B., Calderon, Michael J., Watson, McLane J., Dunstane, Deanna, Watkins, Simon C., Delgoffe, Greg M.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5881463/
https://ncbi.nlm.nih.gov/pubmed/29511066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171068
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