Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar to Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice

BACKGROUND & AIMS: Activating mutations in KRAS are detected in most pancreatic ductal adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in pancreata of mice is sufficient to induce formation of pancreatic intraepithelial neoplasia (PanINs)—a precursor of PDAC. Pancreat...

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Bibliografiska uppgifter
I publikationen:Gastroenterology
Huvudupphovsmän: He, Ping, Yang, Jong Won, Yang, Vincent W., Bialkowska, Agnieszka B.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880723/
https://ncbi.nlm.nih.gov/pubmed/29248441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.12.005
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