Krüppel-like Factor 5, Increased in Pancreatic Ductal Adenocarcinoma, Promotes Proliferation, Acinar to Ductal Metaplasia, Pancreatic Intraepithelial Neoplasia, and Tumor Growth in Mice

BACKGROUND & AIMS: Activating mutations in KRAS are detected in most pancreatic ductal adenocarcinomas (PDACs). Expression of an activated form of KRAS (KrasG12D) in pancreata of mice is sufficient to induce formation of pancreatic intraepithelial neoplasia (PanINs)—a precursor of PDAC. Pancreat...

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Detaylı Bibliyografya
Yayımlandı:Gastroenterology
Asıl Yazarlar: He, Ping, Yang, Jong Won, Yang, Vincent W., Bialkowska, Agnieszka B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880723/
https://ncbi.nlm.nih.gov/pubmed/29248441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.12.005
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