Impaired thermogenesis and sharp increases in plasma triglyceride levels in GPIHBP1-deficient mice during cold exposure

Glycosylphosphatidylinositol-anchored high density lipoprotein–binding protein 1 (GPIHBP1), an endothelial cell protein, binds LPL in the subendothelial spaces and transports it to the capillary lumen. In Gpihbp1(−/−) mice, LPL remains stranded in the subendothelial spaces, causing hypertriglyceride...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Larsson, Mikael, Allan, Christopher M., Heizer, Patrick J., Tu, Yiping, Sandoval, Norma P., Jung, Rachel S., Walzem, Rosemary L., Beigneux, Anne P., Young, Stephen G., Fong, Loren G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880501/
https://ncbi.nlm.nih.gov/pubmed/29449313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M083832
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