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Inhibition of acid sphingomyelinase disrupts LYNUS signaling and triggers autophagy
Activation of the lysosomal ceramide-producing enzyme, acid sphingomyelinase (ASM), by various stresses is centrally involved in cell death and has been implicated in autophagy. We set out to investigate the role of the baseline ASM activity in maintaining physiological functions of lysosomes, focus...
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| Publicado no: | J Lipid Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5880492/ https://ncbi.nlm.nih.gov/pubmed/29378782 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M080242 |
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