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Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium

Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell. As with neurodegenerative diseases, dysfunctional autophagy could contribute to blinding diseases such as macular degeneration. However, precisely how inefficient autophagy promotes retinal damage is un...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Toops, Kimberly A., Tan, Li Xuan, Jiang, Zhichun, Radu, Roxana A., Lakkaraju, Aparna
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4279221/
https://ncbi.nlm.nih.gov/pubmed/25378587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-05-1028
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