Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium (RPE) of aged human donors and in the pigmented Ab...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Kaur, Gulpreet, Tan, Li Xuan, Rathnasamy, Gurugirijha, La Cunza, Nilsa, Germer, Colin J., Toops, Kimberly A., Fernandes, Marie, Blenkinsop, Timothy A., Lakkaraju, Aparna
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2018
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130344/
https://ncbi.nlm.nih.gov/pubmed/30126999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805039115
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