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Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration
Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium (RPE) of aged human donors and in the pigmented Ab...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6130344/ https://ncbi.nlm.nih.gov/pubmed/30126999 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805039115 |
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