Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium (RPE) of aged human donors and in the pigmented Ab...

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Detaylı Bibliyografya
Yayımlandı:Proc Natl Acad Sci U S A
Asıl Yazarlar: Kaur, Gulpreet, Tan, Li Xuan, Rathnasamy, Gurugirijha, La Cunza, Nilsa, Germer, Colin J., Toops, Kimberly A., Fernandes, Marie, Blenkinsop, Timothy A., Lakkaraju, Aparna
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2018
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130344/
https://ncbi.nlm.nih.gov/pubmed/30126999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805039115
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