Aberrant early endosome biogenesis mediates complement activation in the retinal pigment epithelium in models of macular degeneration

Abnormally enlarged early endosomes (EEs) are pathological features of neurodegenerative diseases, yet insight into the mechanisms and consequences of EE expansion remains elusive. Here, we report swollen apical EEs in the retinal pigment epithelium (RPE) of aged human donors and in the pigmented Ab...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Kaur, Gulpreet, Tan, Li Xuan, Rathnasamy, Gurugirijha, La Cunza, Nilsa, Germer, Colin J., Toops, Kimberly A., Fernandes, Marie, Blenkinsop, Timothy A., Lakkaraju, Aparna
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130344/
https://ncbi.nlm.nih.gov/pubmed/30126999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1805039115
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