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Cholesterol-mediated activation of acid sphingomyelinase disrupts autophagy in the retinal pigment epithelium
Autophagy is an essential mechanism for clearing damaged organelles and proteins within the cell. As with neurodegenerative diseases, dysfunctional autophagy could contribute to blinding diseases such as macular degeneration. However, precisely how inefficient autophagy promotes retinal damage is un...
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| Publié dans: | Mol Biol Cell |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Cell Biology
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4279221/ https://ncbi.nlm.nih.gov/pubmed/25378587 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E14-05-1028 |
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