Ozanimod (RPC1063), a selective S1P(R1) and S1P(R5) modulator, reduces chronic inflammation and alleviates kidney pathology in murine systemic lupus erythematosus

Ozanimod (RPC1063) is a specific and potent small molecule modulator of the sphingosine 1-phosphate receptor 1 (S1P(R1)) and receptor 5 (S1P(R5)), which has shown therapeutic benefit in clinical trials of relapsing multiple sclerosis and ulcerative colitis. Ozanimod and its active metabolite, RP-101...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Taylor Meadows, Kristen R., Steinberg, Marcos W., Clemons, Bryan, Stokes, Matthew E., Opiteck, Gregory J., Peach, Robert, Scott, Fiona L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880347/
https://ncbi.nlm.nih.gov/pubmed/29608575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193236
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