Ozanimod (RPC1063) is a potent sphingosine‐1‐phosphate receptor‐1 (S1P(1)) and receptor‐5 (S1P(5)) agonist with autoimmune disease‐modifying activity

BACKGROUND AND PURPOSE: Sphingosine1‐phosphate (S1P) receptors mediate multiple events including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Stimulation of S1P(1) receptors sequesters lymphocyte subsets in peripheral lymphoid organs, preventing their trafficking to i...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Scott, F L, Clemons, B, Brooks, J, Brahmachary, E, Powell, R, Dedman, H, Desale, H G, Timony, G A, Martinborough, E, Rosen, H, Roberts, E, Boehm, M F, Peach, R J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867749/
https://ncbi.nlm.nih.gov/pubmed/26990079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13476
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