Ozanimod (RPC1063) is a potent sphingosine‐1‐phosphate receptor‐1 (S1P(1)) and receptor‐5 (S1P(5)) agonist with autoimmune disease‐modifying activity

BACKGROUND AND PURPOSE: Sphingosine1‐phosphate (S1P) receptors mediate multiple events including lymphocyte trafficking, cardiac function, and endothelial barrier integrity. Stimulation of S1P(1) receptors sequesters lymphocyte subsets in peripheral lymphoid organs, preventing their trafficking to i...

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Enregistré dans:
Détails bibliographiques
Publié dans:Br J Pharmacol
Auteurs principaux: Scott, F L, Clemons, B, Brooks, J, Brahmachary, E, Powell, R, Dedman, H, Desale, H G, Timony, G A, Martinborough, E, Rosen, H, Roberts, E, Boehm, M F, Peach, R J
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2016
Sujets:
Research Papers
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4867749/
https://ncbi.nlm.nih.gov/pubmed/26990079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13476
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