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CYP2C9 polymorphisms in epilepsy: influence on phenytoin treatment

Phenytoin (PHT) is an antiepileptic drug widely used in the treatment of focal epilepsy and status epilepticus, and effective in controlling focal seizures with and without tonic–clonic generalization and status epilepticus. The metabolization of PHT is carried out by two oxidative cytochrome P450 e...

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Publicado en:Pharmgenomics Pers Med
Main Authors: Silvado, Carlos Eduardo, Terra, Vera Cristina, Twardowschy, Carlos Alexandre
Formato: Artigo
Idioma:Inglês
Publicado: Dove Medical Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880189/
https://ncbi.nlm.nih.gov/pubmed/29636628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S108113
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