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What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?: The Importance of Bridging Studies and Species-Independent Correlates of Protection
Animal models have played a pivotal role in all stages of vaccine development. Their predictive value for vaccine effectiveness depends on the pathogen, the robustness of the animal challenge model, and the correlates of protection (if known). This article will cover key questions regarding bridging...
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| Vydáno v: | Cold Spring Harb Perspect Biol |
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| Hlavní autoři: | , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Cold Spring Harbor Laboratory Press
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5880166/ https://ncbi.nlm.nih.gov/pubmed/28348035 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a028902 |
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