Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms

Spleen tyrosine kinase (Syk) is involved in cellular adhesion and also in the activation and development of hematopoietic cells. Syk activation induced by genomic rearrangement has been linked to certain T-cell lymphomas, and Syk inhibitors have been shown to prolong survival of patients with B-cell...

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Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Antenucci, Lina, Hytönen, Vesa P., Ylänne, Jari
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2018
Ämnen:
Signal Transduction
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880128/
https://ncbi.nlm.nih.gov/pubmed/29440271
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.000660
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