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The bacterial pigment pyocyanin inhibits the NLRP3 inflammasome through intracellular reactive oxygen and nitrogen species

Inflammasomes are cytosolic complexes that mature and secrete the inflammatory cytokines interleukin 1β (IL-1β) and IL-18 and induce pyroptosis. The NLRP3 (NACHT, LRR, and PYD domains–containing protein 3) inflammasome detects many pathogen- and danger-associated molecular patterns, and reactive oxy...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Virreira Winter, Sebastian, Zychlinsky, Arturo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5880120/
https://ncbi.nlm.nih.gov/pubmed/29414783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001105
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