Hypoxia leads to significant changes in alternative splicing and elevated expression of CLK splice factor kinases in PC3 prostate cancer cells

BACKGROUND: Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes using the prostate cancer cell line PC3 as a model. Secon...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Bowler, Elizabeth, Porazinski, Sean, Uzor, Simon, Thibault, Philippe, Durand, Mathieu, Lapointe, Elvy, Rouschop, Kasper M. A., Hancock, John, Wilson, Ian, Ladomery, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879922/
https://ncbi.nlm.nih.gov/pubmed/29606096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4227-7
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