Tumor microenvironment–associated modifications of alternative splicing

Pre-mRNA alternative splicing is modified in cancer, but the origin and specificity of these changes remain unclear. Here, we probed ovarian tumors to identify cancer-associated splicing isoforms and define the mechanism by which splicing is modified in cancer cells. Using high-throughput quantitati...

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Main Authors: Brosseau, Jean-Philippe, Lucier, Jean-François, Nwilati, Hanad, Thibault, Philippe, Garneau, Daniel, Gendron, Daniel, Durand, Mathieu, Couture, Sonia, Lapointe, Elvy, Prinos, Panagiotis, Klinck, Roscoe, Perreault, Jean-Pierre, Chabot, Benoit, Abou-Elela, Sherif
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2014
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3895271/
https://ncbi.nlm.nih.gov/pubmed/24335142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.042168.113
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