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Sign of selection on mutation rate modifiers depends on population size

The influence of population size (N) on natural selection acting on alleles that affect fitness has been understood for almost a century. As N declines, genetic drift overwhelms selection and alleles with direct fitness effects are rendered neutral. Often, however, alleles experience so-called indir...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Raynes, Yevgeniy, Wylie, C. Scott, Sniegowski, Paul D., Weinreich, Daniel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879664/
https://ncbi.nlm.nih.gov/pubmed/29531067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715996115
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