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Sign of selection on mutation rate modifiers depends on population size

The influence of population size (N) on natural selection acting on alleles that affect fitness has been understood for almost a century. As N declines, genetic drift overwhelms selection and alleles with direct fitness effects are rendered neutral. Often, however, alleles experience so-called indir...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Raynes, Yevgeniy, Wylie, C. Scott, Sniegowski, Paul D., Weinreich, Daniel M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5879664/
https://ncbi.nlm.nih.gov/pubmed/29531067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715996115
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