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Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

Adhesion G protein-coupled receptors (aGPCRs) have emerged as potential therapeutic targets in multiple cancers and in neurologic diseases. However, there are few modulatory compounds that act on these receptors. The majority of aGPCRs are orphans and a general activation mechanism has only recently...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Mol Pharmacol
Main Authors: Stoveken, Hannah M., Larsen, Scott D., Smrcka, Alan V., Tall, Gregory G.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878671/
https://ncbi.nlm.nih.gov/pubmed/29476042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.117.111476
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