Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which...

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Dades bibliogràfiques
Publicat a:Cell Rep
Autors principals: Kambara, Hiroto, Liu, Fei, Zhang, Xiaoyu, Liu, Peng, Bajrami, Besnik, Teng, Yan, Zhao, Li, Zhou, Shiyi, Yu, Hongbo, Zhou, Weidong, Silberstein, Leslie E., Cheng, Tao, Han, Mingzhe, Xu, Yuanfu, Luo, Hongbo R.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878047/
https://ncbi.nlm.nih.gov/pubmed/29539421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.067
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