Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which...

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Bibliografske podrobnosti
izdano v:Cell Rep
Main Authors: Kambara, Hiroto, Liu, Fei, Zhang, Xiaoyu, Liu, Peng, Bajrami, Besnik, Teng, Yan, Zhao, Li, Zhou, Shiyi, Yu, Hongbo, Zhou, Weidong, Silberstein, Leslie E., Cheng, Tao, Han, Mingzhe, Xu, Yuanfu, Luo, Hongbo R.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878047/
https://ncbi.nlm.nih.gov/pubmed/29539421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.067
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