Gasdermin D Exerts Anti-inflammatory Effects by Promoting Neutrophil Death

Gasdermin D (GSDMD) is considered a proinflammatory factor that mediates pyroptosis in macrophages to protect hosts from intracellular bacteria. Here, we reveal that GSDMD deficiency paradoxically augmented host responses to extracellular Escherichia coli, mainly by delaying neutrophil death, which...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Kambara, Hiroto, Liu, Fei, Zhang, Xiaoyu, Liu, Peng, Bajrami, Besnik, Teng, Yan, Zhao, Li, Zhou, Shiyi, Yu, Hongbo, Zhou, Weidong, Silberstein, Leslie E., Cheng, Tao, Han, Mingzhe, Xu, Yuanfu, Luo, Hongbo R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5878047/
https://ncbi.nlm.nih.gov/pubmed/29539421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.067
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