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Selection and Characterization of a DNA Aptamer Specifically Targeting Human HECT Ubiquitin Ligase WWP1

Nucleic acid aptamers hold promise as therapeutic tools for specific, tailored inhibition of protein targets with several advantages when compared to small molecules or antibodies. Nuclear WW domain containing E3 ubiquitin ligase 1 (WWP1) ubiquitin ligase poly-ubiquitinates Runt-related transcriptio...

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Bibliografske podrobnosti
izdano v:Int J Mol Sci
Main Authors: Tucker, Wesley O., Kinghorn, Andrew B., Fraser, Lewis A., Cheung, Yee-Wai, Tanner, Julian A.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877624/
https://ncbi.nlm.nih.gov/pubmed/29518962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19030763
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