Seihai-to (TJ-90)-Induced Activation of Airway Ciliary Beatings of Mice: Ca(2+) Modulation of cAMP-Stimulated Ciliary Beatings via PDE1

Sei-hai-to (TJ-90, Qing Fei Tang), a Chinese traditional medicine, increases ciliary beat frequency (CBF) and ciliary bend angle (CBA) mediated via cAMP (3′,5′-cyclic adenosine monophosphate) accumulation modulated by Ca(2+)-activated phosphodiesterase 1 (PDE1A). A high concentration of TJ-90 (≥40 μ...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Kogiso, Haruka, Ikeuchi, Yukiko, Sumiya, Masako, Hosogi, Shigekuni, Tanaka, Saori, Shimamoto, Chikao, Inui, Toshio, Marunaka, Yoshinori, Nakahari, Takashi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877519/
https://ncbi.nlm.nih.gov/pubmed/29495403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19030658
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