Hochu-ekki-to enhanced airway ciliary beating by an [Ca2+]i increase via TRPV4 in mice

Background: Hochu-ekki-to (TJ-41, a traditional herbal medicine) is used for preventing airway infections caused by viruss or bacterias in patients with chronic obstructive pulmonary disease (COPD). TJ-41 is known to inhibit viral adhesion and to activate mucosal immune system. However, the effects...

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Main Authors: Yukiko Ikeuchi-Yamamoto, Haruka Kogiso, Daichi Saito, Kotoku Kawaguchi, Riko Ikeda, Shinji Asano, Toshio Inui, Yoshinori Marunaka, Takashi Nakahari
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2022-05-01
Colecção:Phytomedicine Plus
Assuntos:
Bu-zhong-yi-qi-tang
TRPV4
Motile cilia
Intracellular Ca2+ concentration
Mucociliary clearance
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S266703132200029X
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