Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are life-threatening hyperferritinemic systemic inflammatory disorders. Although profound cytotoxic impairment causes familial HLH (fHLH), the mechanisms driving non-fHLH and MAS are largely unknown. MAS occurs in pati...

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Udgivet i:Blood
Main Authors: Weiss, Eric S., Girard-Guyonvarc’h, Charlotte, Holzinger, Dirk, de Jesus, Adriana A., Tariq, Zeshan, Picarsic, Jennifer, Schiffrin, Eduardo J., Foell, Dirk, Grom, Alexei A., Ammann, Sandra, Ehl, Stephan, Hoshino, Tomoaki, Goldbach-Mansky, Raphaela, Gabay, Cem, Canna, Scott W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2018
Fag:
Immunobiology and Immunotherapy
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877443/
https://ncbi.nlm.nih.gov/pubmed/29326099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-12-820852
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