IKKα is required in the intestinal epithelial cells for tumour stemness

BACKGROUND: Colorectal cancer is a common cause of death in developed countries. Progression from adenoma to invasive carcinoma requires accumulation of mutations starting with the Adenomatous Polyposis Coli (Apc) gene. NF-κB signalling is a key element in cancer, mainly related to the activity of I...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Colomer, Carlota, Margalef, Pol, Gonzalez, Jessica, Vert, Anna, Bigas, Anna, Espinosa, Lluis
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2018
Subjects:
Molecular Diagnostics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5877427/
https://ncbi.nlm.nih.gov/pubmed/29438366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.459
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