IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer

Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-κB signaling. Insights into the sources of IKKα(p45) activation and its downstream substrates in the nucleus remain to be define...

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Publicado en:Mol Cell
Main Authors: Colomer, Carlota, Margalef, Pol, Villanueva, Alberto, Vert, Anna, Pecharroman, Irene, Solé, Laura, González-Farré, Mónica, Alonso, Josune, Montagut, Clara, Martinez-Iniesta, Maria, Bertran, Joan, Borràs, Eva, Iglesias, Mar, Sabidó, Eduard, Bigas, Anna, Boulton, Simon J., Espinosa, Lluís
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6715775/
https://ncbi.nlm.nih.gov/pubmed/31302002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.036
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