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IKKα Kinase Regulates the DNA Damage Response and Drives Chemo-resistance in Cancer
Phosphorylated IKKα(p45) is a nuclear active form of the IKKα kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-κB signaling. Insights into the sources of IKKα(p45) activation and its downstream substrates in the nucleus remain to be define...
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| Veröffentlicht in: | Mol Cell |
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| Hauptverfasser: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cell Press
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6715775/ https://ncbi.nlm.nih.gov/pubmed/31302002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.05.036 |
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