Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

Brain subjected to acute ischemic attack caused by an arterial blockage needs immediate arterial recanalization. However, restoration of cerebral blood flow can cause tissue injury, which is termed reperfusion injury. It is important to inhibit reperfusion injury to achieve greater brain protection....

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Bibliographische Detailangaben
Hauptverfasser: Namura, Shobu, Iihara, Koji, Takami, Shinya, Nagata, Izumi, Kikuchi, Haruhiko, Matsushita, Koji, Moskowitz, Michael A., Bonventre, Joseph V., Alessandrini, Alessandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2001
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58770/
https://ncbi.nlm.nih.gov/pubmed/11504919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181213498
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