Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia

Brain subjected to acute ischemic attack caused by an arterial blockage needs immediate arterial recanalization. However, restoration of cerebral blood flow can cause tissue injury, which is termed reperfusion injury. It is important to inhibit reperfusion injury to achieve greater brain protection....

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Bibliografiske detaljer
Main Authors: Namura, Shobu, Iihara, Koji, Takami, Shinya, Nagata, Izumi, Kikuchi, Haruhiko, Matsushita, Koji, Moskowitz, Michael A., Bonventre, Joseph V., Alessandrini, Alessandro
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58770/
https://ncbi.nlm.nih.gov/pubmed/11504919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181213498
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