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Hidden genomic MHC disparity between HLA-matched sibling pairs in hematopoietic stem cell transplantation

Matching classical HLA alleles between donor and recipient is an important factor in avoiding adverse immunological effects in HSCT. Siblings with no differences in HLA alleles, either due to identical-by-state or identical-by-descent status, are considered to be optimal donors. We carried out a ret...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Koskela, Satu, Ritari, Jarmo, Hyvärinen, Kati, Kwan, Tony, Niittyvuopio, Riitta, Itälä-Remes, Maija, Pastinen, Tomi, Partanen, Jukka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876349/
https://ncbi.nlm.nih.gov/pubmed/29599509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23682-y
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