RING tetramerization is required for nuclear body biogenesis and PML sumoylation

ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the SUMO E2 enzyme. Here, usi...

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Publicat a:Nat Commun
Autors principals: Wang, Pengran, Benhenda, Shirine, Wu, Haiyan, Lallemand-Breitenbach, Valérie, Zhen, Tao, Jollivet, Florence, Peres, Laurent, Li, Yuwen, Chen, Sai-Juan, Chen, Zhu, de Thé, Hugues, Meng, Guoyu
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876331/
https://ncbi.nlm.nih.gov/pubmed/29599493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03498-0
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