RING tetramerization is required for nuclear body biogenesis and PML sumoylation

ProMyelocyticLeukemia nuclear bodies (PML NBs) are stress-regulated domains directly implicated in acute promyelocytic leukemia eradication. Most TRIM family members bind ubiquitin E2s and many acquire ligase activity upon RING dimerization. In contrast, PML binds UBC9, the SUMO E2 enzyme. Here, usi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Wang, Pengran, Benhenda, Shirine, Wu, Haiyan, Lallemand-Breitenbach, Valérie, Zhen, Tao, Jollivet, Florence, Peres, Laurent, Li, Yuwen, Chen, Sai-Juan, Chen, Zhu, de Thé, Hugues, Meng, Guoyu
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876331/
https://ncbi.nlm.nih.gov/pubmed/29599493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03498-0
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