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Internal tandem duplication mutations in the tyrosine kinase domain of FLT3 display a higher oncogenic potential than the activation loop D835Y mutation

Acute myeloid leukemia (AML) remains the most common form of acute leukemia among adults and accounts for a large number of leukemia-related deaths. Mutations in FMS-like tyrosine kinase 3 (FLT3) is one of the most prevalent findings in this heterogeneous disease. The major types of mutations in FLT...

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Bibliografiske detaljer
Udgivet i:Ann Hematol
Main Authors: Marhäll, Alissa, Heidel, Florian, Fischer, Thomas, Rönnstrand, Lars
Format: Artigo
Sprog:Inglês
Udgivet: Springer Berlin Heidelberg 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876274/
https://ncbi.nlm.nih.gov/pubmed/29372308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00277-018-3245-5
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