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Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

The concept for cellular immunotherapy of solid tumors relies heavily on the capacity of class I MHC-restricted cytotoxic T lymphocytes (CTLs) to eliminate tumor cells. However, tumors often have managed to escape from the cytolytic machinery of these effector cells. Therefore, it is very important...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Medema, J. P., de Jong, J., Peltenburg, L. T. C., Verdegaal, E. M. E., Gorter, A., Bres, S. A., Franken, K. L. M. C., Hahne, M., Albar, J. P., Melief, C. J. M., Offringa, R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58761/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11562487/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.201398198
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