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Reduced brain insulin signaling: a seminal process in Alzheimer’s disease pathogenesis

The synaptic dysfunction and death of neurons that mediate memory and cognition account together for the behavioral symptoms of Alzheimer’s disease (AD). Reduced insulin signaling in the brain is a hallmark of AD patients, even in the absence of systemic type 1 or type 2 diabetes, prompting some res...

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Detalhes bibliográficos
Publicado no:Neuropharmacology
Main Authors: Bloom, George S., Lazo, John S., Norambuena, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5876069/
https://ncbi.nlm.nih.gov/pubmed/28965829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.09.016
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