Targeted adenovirus-induced expression of IL-10 decreases thymic apoptosis and improves survival in murine sepsis

Sepsis remains a significant clinical conundrum, and recent clinical trials with anticytokine therapies have produced disappointing results. Animal studies have suggested that increased lymphocyte apoptosis may contribute to sepsis-induced mortality. We report here that inhibition of thymocyte apopt...

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Bibliografiske detaljer
Main Authors: Oberholzer, Caroline, Oberholzer, Andreas, Bahjat, Frances R., Minter, Rebecca M., Tannahill, Cynthia L., Abouhamze, Amer, LaFace, Drake, Hutchins, Beth, Clare-Salzler, Michael J., Moldawer, Lyle L.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58759/
https://ncbi.nlm.nih.gov/pubmed/11553765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.181338198
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