Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase
Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among various classes of oxidative DNA damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is most important because of its abundance and mutagenicity. The MTH1 ge...
Zapisane w:
| Wydane w: | Proc Natl Acad Sci U S A |
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| Główni autorzy: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
National Academy of Sciences
2001
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC58751/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11572992/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.191086798 |
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