Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

Oxygen radicals, which can be produced through normal cellular metabolism, are thought to play an important role in mutagenesis and tumorigenesis. Among various classes of oxidative DNA damage, 8-oxo-7,8-dihydroguanine (8-oxoG) is most important because of its abundance and mutagenicity. The MTH1 ge...

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Main Authors: Tsuzuki, Teruhisa, Egashira, Akinori, Igarashi, Hisato, Iwakuma, Tomoo, Nakatsuru, Yoko, Tominaga, Yohei, Kawate, Hisaya, Nakao, Kazuki, Nakamura, Kenji, Ide, Fumio, Kura, Shinobu, Nakabeppu, Yusaku, Katsuki, Motoya, Ishikawa, Takatoshi, Sekiguchi, Mutsuo
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC58751/
https://ncbi.nlm.nih.gov/pubmed/11572992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191086798
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