The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells

Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island. These genotoxic metabolites are produced by pks-encoded peptide-polyketide synthases as inactive prodrugs called precolibactins,...

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Publicado en:mBio
Autores principales: Bossuet-Greif, Nadège, Vignard, Julien, Taieb, Frédéric, Mirey, Gladys, Dubois, Damien, Petit, Claude, Oswald, Eric, Nougayrède, Jean-Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874909/
https://ncbi.nlm.nih.gov/pubmed/29559578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02393-17
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