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The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells
Colibactins are hybrid polyketide-nonribosomal peptides produced by Escherichia coli, Klebsiella pneumoniae, and other Enterobacteriaceae harboring the pks genomic island. These genotoxic metabolites are produced by pks-encoded peptide-polyketide synthases as inactive prodrugs called precolibactins,...
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| Veröffentlicht in: | mBio |
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| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5874909/ https://ncbi.nlm.nih.gov/pubmed/29559578 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02393-17 |
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