Functional Optimization of Broadly Neutralizing HIV-1 Antibody 10E8 by Promotion of Membrane Interactions

The 10E8 antibody targets a helical epitope in the membrane-proximal external region (MPER) and transmembrane domain (TMD) of the envelope glycoprotein (Env) subunit gp41 and is among the broadest known neutralizing antibodies against HIV-1. Accordingly, this antibody and its mechanism of action val...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Rujas, Edurne, Leaman, Daniel P., Insausti, Sara, Ortigosa-Pascual, Lei, Zhang, Lei, Zwick, Michael B., Nieva, José L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874428/
https://ncbi.nlm.nih.gov/pubmed/29386285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02249-17
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