Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner

The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers of B cells. However, it has remained...

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Udgivet i:Front Immunol
Main Authors: Liu, Rui, King, Ashleigh, Bouillet, Philippe, Tarlinton, David M., Strasser, Andreas, Heierhorst, Jörg
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5874283/
https://ncbi.nlm.nih.gov/pubmed/29623080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00592
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