Requirement for Rictor in homeostasis and function of mature B lymphoid cells

The mammalian target of rapamycin (mTOR), an essential serine/threonine kinase, functions in biochemically distinct multiprotein complexes, but little is known about roles of the complexes in B cells. The acutely rapamycin-sensitive mTOR complex 1 (mTORC1) is defined by a core subunit Raptor, wherea...

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Autors principals: Lee, Keunwook, Heffington, Lindsey, Jellusova, Julia, Nam, Ki Taek, Raybuck, Ariel, Cho, Sung Hoon, Thomas, James W., Rickert, Robert C., Boothby, Mark
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2013
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790507/
https://ncbi.nlm.nih.gov/pubmed/23958952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-477505
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