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Alu-mediated inactivation of the human CMP- N-acetylneuraminic acid hydroxylase gene

Inactivation of the CMP-N-acetylneuraminic acid hydroxylase gene has provided an example of human-specific genomic mutation that results in a widespread biochemical difference between human and nonhuman primates. We have found that, although a region containing a 92-bp exon and an AluSq element in t...

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Autores principales: Hayakawa, Toshiyuki, Satta, Yoko, Gagneux, Pascal, Varki, Ajit, Takahata, Naoyuki
Formato: Artigo
Lenguaje:Inglês
Publicado: The National Academy of Sciences 2001
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC58741/
https://ncbi.nlm.nih.gov/pubmed/11562455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.191268198
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