Fixation of the Human-Specific CMP-N-Acetylneuraminic Acid Hydroxylase Pseudogene and Implications of Haplotype Diversity for Human Evolution

The human CMP-N-acetylneuraminic acid hydroxylase gene (CMAH) suffered deletion of an exon that encodes an active center for the enzyme ∼3.2 million years ago (MYA). We analyzed a 7.3-kb intronic region of 132 CMAH genes to explore the fixation process of this pseudogene and the demographic implicat...

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Main Authors: Hayakawa, Toshiyuki, Aki, Ikuko, Varki, Ajit, Satta, Yoko, Takahata, Naoyuki
Formato: Artigo
Idioma:Inglês
Publicado: Copyright © 2006 by the Genetics Society of America 2006
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Investigations
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456212/
https://ncbi.nlm.nih.gov/pubmed/16272417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.105.046995
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